The research of composite laminates after low-velocity impact compressive failure has important significance in composite structure design. According to the ASTM D 7136 and 7137 test standard, the low-velocity impact test and compressive test of CCF300/5228 laminate were conducted. Basing on the cumulative damage theory, a model which setted the damages obtained from the low-velocity impact numerical simulation as the initial damages was established to explore compression failure of composite laminates with low-velocity impact damage. In this model , the strain failure criterion was applied and the degradation of the material properties was considered. Finally, the damage evolution and residual compressive strength of CCF300/5228 laminates were studied by this model. The results showed that, this model can explain the failure phenomenon well during the experiment and predict the residual compressive strength of laminates accurately. And it’s proved that, the damage propagation and failure mode from the model agreed with the experimental results well.