The accurate prediction of boundary layer transition of aircraft is the key of getting laminar airfoil with high performance. This paper selects the Gamma-Theta transition model coupled with the SST k-w turbulence model based on the characteristics of numerical simulation of boundary layer and CFD technology, to achieve the accurate prediction of airfoil boundary layer transition of different types. At the meantime, enhancing the grid equality can increase the computing accuracy of the aerodynamics characteristics of airfoil to some extent, and obtain more precise result of transition location.