Monotonic tension tests and tension-tension fatigue tests combined with microscopic observation by scanning electron microscopy (SEM) were performed to investigate the fatigue behavior and life prediction of 2D C/SiC. The results show that C/SiC exhibits metal-similar ductile fracture behavior. The fatigue limit is about 85% of ultimate tensile strength(UTS), which indicates that C/SiC has excellent fatigue performance under room temperature. The tendency of the S-N curve of the notched specimen is consistent with the curve of the smooth specimen. But the curve of the notched specimen is higher than that of the smooth specimen, due to the notch insensitivity and notch blunted effect of composite materials. According to the test results, a fatigue prediction model based on the nominal stress is presented.