The application of titanium alloy for the commercial aircraft fuselage can make the structure weight saving, and improve fatigue life and the corrosion-resistant capability. The quantity of titanium alloy increased in the most advanced commercial aircrafts. The properties and advantages of the titanium alloys have been described detailedly. The recent applications of titanium alloys and fasteners on commercial aircrafts have been introduced and the reason has been analysed. The opportunity and the challenge of titanium alloy applications have also been presented.