In order to get the benefits of non-conventional configuration in regional aircraft design to improve its performance, and avoid its weaknesses, the blended configuration with non-conventional and conventional layout is proposed. This configuration improves the aerodynamic characteristics of re-gional aircraft utilizing the advantages of the flying wing, meanwhile avoid the negative aspects. By improve and optimize a large number of design programs through gradual iteration, the blended configuration with non-conventional and conventional layout is obtained. The aerodynamic performance of this layout is better than the new generation of regional aircraft. Such as, the cruise lift to drag ratio is increased about 7.5%, drag divergence Mach number is increased about 7.5%, and cruise factor is increased about 7.5%. At the same time it has good airport adaptability. And the program has the potential to further optimize the performance improvements, and laid a foundation for the research unconventional layout of the transport aircraft in the future.