As the representative of the new generation large commercial aircraft, the design of a large quantity of big cabin windows on A380 is one of the key points. It shows the research and analysis of the window frame assembly and window frame structure from the aspects of conception comparison, load condition of components, material selection and so on, aiming at introducing the experience of the design of cabin window frames of A380. It demonstrates a successful design case of large commercial aircraft cabin window frame, through the presentation of detail parts and joint, selection of materials for main structure and the comparison of FEM analysis result and static test data, provided as the design reference of the subsequent aircraft window frame.