The design of Least Risk Bomb Location (LRBL) is directly related to the flight safety of transport aircraft, and the research on airworthiness compliance verification of LRBL in our country is still in its infancy.According to LRBL airworthiness requirements and AC 25.795-6 ,based on design and layout of structures and systems around LRBL and the secondary effects and countermeasures after the explosion, the research progress of the aircraft structure response characteristics under internal explosive load, impact damage of human, explosion-proof container design and projectile damage caused by explosion fragments is reviewed. The related project studies to study the response of fuselage structures under internal explosive load are described briefly.