Aiming at optimal airspace layout of electronic jamming during air fighter’s penetration operation, the range of radar detection under electronic jamming, route safety interval, and effective jamming time under electronic interference were described. In order to achieve the safety penetration of the penetration fighters, to ensure the safety of the jammer itself, and to achieve the purpose of efficient use of airspace resources, the optimal airspace layout model of the electronic jamming machine was established, and Improved Grey Wolf Optimization (IGWO) was used to find the optimal airspace reference point. In order to avoid falling into the local optimum, the linear adjustment parameter in original grey wolf optimization was changed to a non-linear one, and the memory function in the particle swarm optimization was added. The simulation results showed that Improved Grey Wolf Optimization (IGWO) was superior to the original grey wolf optimization algorithm and particle swarm optimization, could quickly find the optimal airspace reference point to complete a specific penetration task, and then designed the optimal airspace of the electronic jamming aircrafts. It also proved that the model was scientific and effective.