Large-scale aerial refueling is complex system engineering, and the influencing factors are closely related to the tanker and the receiver. Due to the special layout of single wing, large wingspan, high vertical tail and large landing gear fairing on the large tanker (soft refueling), the aerodynamic interference between tanker, hose cone sleeve and tanker becomes very complicated during the process of refueling docking in air formation. By analyzing the main characteristics of domestic and foreign large-scale refueling and advanced refueling aircraft, this paper summarizes the aerodynamic interference between refueling and refueling aircraft in the process of air refueling docking, deeply studies the typical system of large-scale air refueling and refueling formation and the procedures of air refueling and refueling formation, and puts forward the possible safety pairs for large-scale air refueling and refueling. The validation factors of the impact of docking control are analyzed, and the docking safety design method of large-scale aerial refueling formation flight is given.