Cloud operation is a new operational mode brought by cloud computing technology in the military field. In the future aviation and space information confrontation, cloud operation will have the invisible power application and the combination of virtual and real combat operations. This paper analyzes the construction requirements of aviation and space information equipment system. Based on the concept of cloud computing and cloud operation, aviation and space information equipment system is constructed. The paper discusses the enlightenment of the cloud operation concept to the construction of aviation and space information equipment system. The revelations are emphasizing the research on the winning mechanism of cloud operation, enhancing equipment integration capability, focusing on reliability and safety, adhering to overall coordination, etc.