Regional freight UAVs provide a more economical and efficient transportation mode for freight in remote areas, mountains, plateaus, islands and cities, and play an important role in emergency rescue and supplies at wartimes. This paper reviews the development of regional freight UAVs, compares the competitive advantages between regional freight UAVs, human aircraft, and land traffics, and discusses the relatively safe running mode of freight UAVs under the current technical status, which is “the pipeline flight of point to point”. Finally, Key technologies of regional freight UAVs are analyzed, including: the technology of airworthiness, aircraft platforms, data link, navigation and autonomous take-off and landing technology and so on. The application of regional freight UAVs need to carry out systematic construction, pay attention to operational risk, and Laws and regulations for UAVs, airspace management, flight management, airport facilities and other construction work must also be attached importance, in addition of aircraft platforms.