Some thin-walled structures in aircraft structures inevitably bear out-of-plane bending, affecting the safety of aircraft significantly. The FRACN3D-ABAQUS simulation was carried out in this paper to understand this issue. Effects of boundary restraint and initial crack shape on this kind of fatigue crack propagation were studied. The applicability of the simulation method was evaluated. Following results were obtained: applying the crack surface contact and weaker boundary constrains in simulations will increase the calculated Stress Intensity Factor (SIF); the initial hole corner crack has a higher crack propagation rate than the initial surface crack around the hole; the FRACN3D-ABAQUS simulation method cannot simulate the crack propagation in the compressed surface, where the crack is unable to propagate.