As aircraft systems become increasingly highly integrated and automated, pilots are often ill-prepared to cope with an actual emergency or failure, and their corrective actions may be erroneous, delayed or incomplete. Therefore, there is an urgent need to consider flight crew human factors in system safety assessment. By analyzing the requirements of CCAR25.1309(b)(c) and failure processing process of flight crew, based on the failure conditions in functional hazard assessment, the method of requirements capture and analysis of flight crew human factors is proposed. By applying these methods in the aircraft development, top down design for safety which from failure condition to alert and procedures is achieved, and a complete chain of compliance evidence for human factor of safety is established, to demonstrate compliance with CCAR25.1309(b)(c).