Least risk bomb location structure is a device for placing suspicious explosives on the aircraft. Exploring the influence of structure size and explosive location on its anti-explosion performance can provide a reference for improving the design. Based on the method of combining orthogonal experimental design with numerical simulation, the maximum strain and deformation of each dangerous part of LRBL structure are used as evaluation indicators. The range analysis method and variance analysis method are respectively used to carry out parameter sensitivity analysis on the five influencing factors of the tank wall thickness, bottom cover thickness, connection boss thickness, shear pin diameter and explosive position of LRBL structure. The results show that when the explosive equivalent was determined as 200g, the significant degree of influence of each factor on the antiknock performance of the LRBL structure from large to small was as follows: explosive position, tank wall thickness, bottom cover thickness, boss thickness and shear pin diameter; Based on comprehensive analysis of evaluation indicators, the LRBL structural design scheme at the optimal level of each factor is obtained. The research results have guiding significance and reference value for the application of LRBL structure in engineering practice.